mHealth Biomarkers

mHealth Biomarkers

mHealth Biomarkers

A biomarker is an objective indicator of a physical or state that can be observed and measured accurately and reproducibly. The World Health Organization has defined a biomarker as "any substance structure or process that can be measured in the body or its products and influence or predict the incidence of outcome or disease." [1, 2]

Team members

Faculty
James M. Rehg (Thrust 2 Lead, Georgia Tech)
Deepak Ganesan (UMass Amherst)
Benjamin Marlin (UMass Amherst)
Mustafa al'Absi (Minnesota)
Santosh Kumar (Memphis)
Gregory Abowd (Georgia Tech)
Cho Lam (Utah)
Bonnie Spring (Northwestern)
David Wetter (Utah)

Students
Soujanya Chatterjee (Memphis)
Addison Mayberry (UMass)
Nazir Saleheen (Memphis)
Rumanna Bari (Memphis)

MD2K has two biomedical applications for its research, detection of smoking relapse among abstinent smokers, and of onset of congestion in congestive heart failure patients (CHF). Once identified, researchers focus on the risk factors for smoking lapses and CHF.

Since it began in 2014, MD2K has successfully identified robust markers of stress, smoking, craving (eating/smoking), fatigue, eating and TV viewing (for detecting exposures to alcohol ads).

To identify and validate these biomarkers, MD2K researchers have correlated sensor data with self-reports known as Ecological Momentary Assessments (EMAs) to identify biomarkers within the sensor data. These biomarkers -- of stress, craving, smoking, drug use, and eating -- are exposed within the millions of bits of sensor data by using computational models that identify combinations within the sensor data.

For example, a wrist sensor might identify a hand movement to the mouth that could mean anything. But, when that information is combined with respiratory sensor that shows inhalation and exhalation, the moment a puff on a cigarette occures becomes clear.

Methodological advances resulted in novel methods for:

• Efficiently computing biomarker features from compressively sampled ECG data
• Structured prediction models to compute biomarkers in the presence of temporally imprecise labels
• Better lab-to-field generalizability in biomarker computation by addressing covariate shift and prior probability shift (in feature computation).

Data science research on discovery of mHealth predictors led to a new pattern mining approach for identifying a significant stress episode from the (minute-level) time-series of stress biomarkers and a discovery dashboard (with interactive motif discovery capabilities) to facilitate visual exploration of multivariate biomarker time series. Modeling advances resulted in a new latent state model for modeling patterns in mobile health event data. The model combines the benefits of a continuous time Hidden Markov Model (CT-HMM) for capturing patterns in event data with irregular arrival times with survival analysis, which provides interpretable models for predicting the risk of adverse events over future time intervals.

[1] WHO International Programme on Chemical Safety Biomarkers in Risk Assessment: Validity and Validation. 2001. Retrieved from http://www.inchem.org/documents/ehc/ehc/ehc222.htm.

[2] Strimbu, K., & Tavel, J. A. (2010). What are Biomarkers? Current Opinion in HIV and AIDS, 5(6), 463–466. http://doi.org/10.1097/COH.0b013e32833ed177

Publications

  1. Rummana Bari, Roy J Adams, Md. Mahbubur Rahman, Megan Battles Parsons, Eugene H Buder and Santosh Kumar.
    rConverse: Moment by Moment Conversation Detection Using a Mobile Respiration Sensor. Proc. ACM Interact. Mob. Wearable Ubiquitous Technol. 2(1):2:1–2:27, 2018. URL, DOI BibTeX

  2. Edison Thomaz, Abdelkareem Bedri, Temiloluwa Prioleau, Irfan Essa and Gregory D Abowd.
    Exploring Symmetric and Asymmetric Bimanual Eating Detection with Inertial Sensors on the Wrist. In Proceedings of the 1st Workshop on Digital Biomarkers. 2017, 21–26. URL, DOI BibTeX

  3. James M Rehg, Susan A Murphy and Santosh Kumar (eds.).
    Detecting Eating and Smoking Behaviors Using Smartwatches
    . pages 175–201, Springer International Publishing, 2017. URL, DOI BibTeX

  4. Rostaminia Soha, Mayberry Addison, Ganesan Deepak, Marlin Benjamin and Gummeson Jeremy.
    iLid: Low-power Sensing of Fatigue and Drowsiness Measures on a Computational Eyeglass. Proc. ACM Interact. Mob. Wearable Ubiquitous Technol. 1(2):23:1–23:26, 2017. URL, DOI BibTeX

  5. Hillol Sarker, Matthew Tyburski, Md Mahbubur Rahman, Karen Hovsepian, Moushumi Sharmin, David H Epstein, Kenzie L Preston, Debra C Furr-Holden, Adam Milam, Inbal Nahum-Shani, Mustafa and Santosh Kumar.
    Finding Significant Stress Episodes in a Discontinuous Time Series of Rapidly Varying Mobile Sensor Data. In Proceedings of the 2016 CHI Conference on Human Factors in Computing Systems. 2016, 4489–4501. URL, DOI BibTeX

  6. Soujanya Chatterjee, Karen Hovsepian, Hillol Sarker, Nazir Saleheen, Mustafa al’Absi, Gowtham Atluri, Emre Ertin, Cho Lam, Andrine Lemieux, Motohiro Nakajima, Bonnie Spring, David W Wetter and Santosh Kumar.
    mCrave: Continuous Estimation of Craving During Smoking Cessation. In Proceedings of the 2016 ACM International Joint Conference on Pervasive and Ubiquitous Computing. 2016, 863-874. URL, DOI BibTeX

  7. E Thomaz, C Zhang, I Essa and G D Abowd.
    Inferring Meal Eating Activities in Real World Settings from Ambient Sounds: A Feasibility Study. In Proceedings of the 20th International Conference on Intelligent User Interfaces (IUI '15). 2015, 427–431. URL, DOI BibTeX

  8. Ashley P Kennedy, David H Epstein, Michelle L Jobes, Daniel Agage, Matthew Tyburski, Karran A Phillips, Amin Ahsan Ali, Rummana Bari, Syed Monowar Hossain, Karen Hovsepian, Mahbubur Rahman, Emre Ertin, Santosh Kumar and Kenzie L Preston.
    Continuous In-The-Field Measurement of Heart Rate: Correlates of Drug Use, Craving, Stress, and Mood in Polydrug Users. Drug and Alcohol Dependence (0):-, 2015. URL, DOI BibTeX

  9. F Cordeiro, D Epstein, E Thomaz, E Bales, A K Jagannathan, G D Abowd and J Fogarty.
    Barriers and Negative Nudges: Exploring Challenges in Food Journaling. In Proceedings of the 33rd Annual ACM Conference on Human Factors in Computing Systems (CHI ’15). 2015. URL BibTeX

  10. Yin Li, Zhefan Ye and James M Rehg.
    Delving Into Egocentric Actions. In The IEEE Conference on Computer Vision and Pattern Recognition (CVPR). 2015. URL BibTeX

  11. Edison Thomaz, Irfan Essa and Gregory D Abowd.
    A Practical Approach for Recognizing Eating Moments with Wrist-mounted Inertial Sensing. In Proceedings of the 2015 ACM International Joint Conference on Pervasive and Ubiquitous Computing. 2015, 1029–1040. URL, DOI BibTeX

  12. Karen Hovsepian, Mustafa , Emre Ertin, Thomas Kamarck, Motohiro Nakajima and Santosh Kumar.
    cStress: Towards a Gold Standard for Continuous Stress Assessment in the Mobile Environment. In Proceedings of the 2015 ACM International Joint Conference on Pervasive and Ubiquitous Computing. 2015, 493–504. URL, DOI BibTeX

  13. Nazir Saleheen, Amin Ahsan Ali, Syed Monowar Hossain, Hillol Sarker, Soujanya Chatterjee, Benjamin Marlin, Emre Ertin, Mustafa and Santosh Kumar.
    puffMarker: A Multi-sensor Approach for Pinpointing the Timing of First Lapse in Smoking Cessation. In Proceedings of the 2015 ACM International Joint Conference on Pervasive and Ubiquitous Computing. 2015, 999–1010. URL, DOI BibTeX

  14. A Parate, M Chiu, C Chadowitz, D Ganesan and E Kalogerakis.
    RisQ: Recognizing Smoking Gestures with Inertial Sensors on a Wristband. In Proceedings of the 12th Annual International Conference on Mobile Systems, Applications, and Services (MobiSys '14). 2014, 149–161. URL, DOI BibTeX

  15. A Mayberry, P Hu, B Marlin, C Salthouse and D Ganesan.
    iShadow: Design of a Wearable, Real-time Mobile Gaze Tracker. In Proceedings of the 12th Annual International Conference on Mobile Systems, Applications, and Services (MobiSys '14). 2014, 82–94. URL, DOI BibTeX

  16. S M Hossain, A A Ali, M M Rahman, E Ertin, D Epstein, A Kennedy, K Preston, A Umbricht, Y Chen and S Kumar.
    Identifying Drug (Cocaine) Intake Events from Acute Physiological Response in the Presence of Free-living Physical Activity.. Proceedings of the 13th ACM/IEE Conference on Information Processing in Sensor Networks 2014:71–82, 2014. URL BibTeX

  17. Md Mahbubur Rahman, Amin Ahsan Ali, Kurt Plarre, Mustafa Al'Absi, Emre Ertin and Santosh Kumar.
    mconverse: Inferring conversation episodes from respiratory measurements collected in the field. In Proceedings of the 2nd Conference on Wireless Health. 2011, 10. URL BibTeX

 

 

 

Copyright © 2020 MD2K. MD2K was established by the National Institutes of Health Big Data to Knowledge Initiative (Grant #1U54EB020404)
Team: Cornell Tech, GA Tech, Harvard, U. Memphis, Northwestern, Ohio State, UCLA, UCSD, UCSF, UMass, U. Michigan, U. Utah, WVU